Browse our latest Evolutionary Biology articles

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    1. Evolutionary Biology
    2. Medicine

    Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

    Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
    Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Stable antibiotic resistance and rapid human adaptation in livestock-associated MRSA

    Marta Matuszewska, Gemma GR Murray ... Lucy A Weinert
    The dominant MRSA circulating in European livestock has stably maintained genes associated with resistance to antibiotic treatments over several decades and when it is transmitted to humans it can rapidly acquire genes that allow it to evade human immune responses.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity

    Isabel Nocedal, Michael T Laub
    Ancestral reconstruction of a signaling pathway reveals the mutations responsible for producing specificity of the two paralogous pathways produced by a duplication event.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Selection for infectivity profiles in slow and fast epidemics, and the rise of SARS-CoV-2 variants

    François Blanquart, Nathanaël Hozé ... Simon Cauchemez
    Selection acting on SARS-CoV-2 variants altering the infectivity profile depends on levels of transmission in the community, and this dependence is used to infer Alpha and Delta variants infectivity profiles.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and Ageing-Related metabolites

    J Kyle Medley, Jenna Persons ... Nicolas Rohner
    Metabolomics data reveals unique metabolic insights into how cavefish adapt to nutrient limited environments while staying healthy.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Complex fitness landscape shapes variation in a hyperpolymorphic species

    Anastasia V Stolyarova, Tatiana V Neretina ... Georgii A Bazykin
    Some deleterious mutations co-occurring within a genome can compensate each other, and this affects patterns of polymorphism, particularly in highly polymorphic species.
    1. Evolutionary Biology
    2. Neuroscience

    Alone, in the dark: The extraordinary neuroethology of the solitary blind mole rat

    Yael Kashash, Grace Smarsh ... Tali Kimchi
    A new ethologically relevant model for investigating the neurobiology of solitary, asocial behavior in the blind mole rat.
    1. Evolutionary Biology

    Squamation and scale morphology at the root of jawed vertebrates

    Yajing Wang, Min Zhu
    New morphological data of a primitive placoderm fish demonstrate both high regionalization of squamation and the bipartite histological structure of scale are plesiomorphic for jawed vertebrates.
    1. Evolutionary Biology

    Palatal morphology predicts the paleobiology of early salamanders

    Jia Jia, Guangzhao Li, Ke-Qin Gao
    Salamanders originate as metamorphosed with a biphasic lifestyle as shown by the palate shape and several non-shape features associated with the vomerine teeth, with diverse ecological types displayed in living species achieved in the Early Cretaceous.
    1. Developmental Biology
    2. Evolutionary Biology

    Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

    Jonathan E Phillips, Maribel Santos ... Duojia Pan
    Genome editing in a close unicellular relative of animals suggests a premetazoan function of the Hippo pathway effector YAP/TAZ/Yorkie in the regulation of cytoskeletal dynamics and multicellular morphogenesis but not proliferation.