Browse our latest Genetics and Genomics articles

The transcriptional cofactor HPK-1 (homeodomain-interacting protein kinase) functions as a key regulator of multiple proteostatic stress responses, each originating from discrete neuronal subtypes within the Caenorhabditis elegans nervous system to preserve neuronal health and maintain organismal proteostasis during normal aging.

Continuing advances in functional genomics will enable systematic characterization of how non-coding genetic variation at enhancers impacts developmental diseases.

A genetic screen identifies a lipid pathway which impacts the endoplasmic reticulum unfolded protein response and highlights a mechanism through which lipid disequilibrium might facilitate the progression of proteopathic diseases.

Genes of the MICOS complex are a major candidate pathway to be potentially linked to defects in cardiomyocyte growth and differentiation in Hypoplastic left heart syndrome (HLHS), and relevant for elucidating the polygenic nature of HLHS and other CHDs.

In the model plant Arabidopsis thaliana genome dynamic exchanges of histone variants control the organization of histone modifications into chromatin states, acting as molecular landmarks.

Rice transposable element polymorphisms already present in the wild ancestors are associated with transcriptional variability and have been differentially selected in indica and japonica populations.

A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.

Genomic analysis has shed light on how hadal snailfish have adapted to living at depths of several thousand metres.

Biallelic MAD2L1BP variants contribute to oocyte metaphase I arrest in women with primary infertility and p31^comet is required for human oocyte maturation.