Uri Seroussi, Andrew Lugowski ... Julie M Claycomb
Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.
Carol A Edwards, William MD Watkinson ... Anne C Ferguson-Smith
Genes with parent-of-origin specific expression are not as numerous as previously reported and validated parentally-biased expressed genes tend to be peripheral to known imprinted domains indicating shared regional control.
Vera Rinaldi, Kathleen Messemer ... Oliver J Rando
Tissue-specific Cre recombinase often drives 'off-target' reporter activity in the male reproductive tract, suggesting the potential for inter-tissue RNA or protein trafficking in control of sperm maturation or other aspects of reproductive physiology.
Phenome-wide estimation of causality between plasma triglyceride levels and disease risk highlights associations with atherosclerotic disease and other unrelated diseases.
Krithika Venkataraman, Nadav Shai ... Leslie B Vosshall
Two novel, tightly linked, and rapidly evolving genes encoding small secreted proteins are necessary for female mosquitoes to protect their retained eggs during extended periods of drought.
Xinzhu Wei, Christopher R Robles ... Sriram Sankararaman
Genetic variants introgressed into modern humans from Neanderthals tend to be depleted in their contribution to heritable trait variation relative to modern human variants consistent with the action of purifying selection.
Monica Sanchez-Contreras, Mariya T Sweetwyne ... Scott R Kennedy
The accumulation of somatic mutations during aging is not uniform across tissue types and, in addition, shows significant variability in the source of mutation that can be modified by small molecule interventions.
Erik Clark, Margherita Battistara, Matthew A Benton
A retracting gradient of the transcription factor Tailless spatiotemporally patterns the Drosophila tail region by modulating the intrinsic dynamics of a regulatory network involving the timer genes caudal, Dichaete, and odd-paired.
Aaron W Jurrjens, Marcus M Seldin ... Anna C Calkin
The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated.
Quantitative proteomic analysis shows that recessive Ryr1 mutations not only decrease the content of RyR1 protein in muscle, but also affect the content of many other proteins involved in a variety of biological processes.
