Browse our latest Genetics and Genomics articles

Loss-of-function mutations in human genes are an important class of disease causing variation, and estimates of their effects on evolutionary fitness can be used to evaluate their pathogenicity.

Effects of ecdysone on sleep are mediated through lipid metabolism in cortex glia.

Modest changes in expression of interacting dose-dependent transcription factors Tbx5 and Prrx1, caused by disease-associated common regulatory variants, significantly impact on the cardiac gene regulatory network and disease susceptibility.

In a prospective, population-based cohort, high polygenic risk and infection with Fusobacterium nucleatum have a small, yet independent impact on coronary heart disease risk.

The transcriptional network for the GAL regulon induction in the pathogenic fungus Candida albicans represents an important advance in the evolution of the regulatory circuits, and would make a nice addition to the textbook version of eukaryotic gene regulation.

Biochemical and biological characterization of insulator complex SUMM4 reveals that, in addition to disrupting enhancer–promoter interactions and establishing chromatin barriers, it functions to delay DNA replication, thus implicating architectural proteins in shaping spatiotemporal patterns of replication.

Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.

Genetic conflicts between sex chromosomes during spermatogenesis may drive the rapid evolution, function, and turnover of some sperm nuclear basic proteins in Drosophila species.

Analysis of population diversity of SARS-CoV-2 revealed positive epistasis between sites carrying mutations characterizing rapidly expanding lineages.

Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.