Browse our latest Genetics and Genomics articles

An integrated framework for in vivo base edting allows to scalably validate candidate genes and DNA variants.

Transiently reprogramming human fibroblasts up to the maturation phase rejuvenates cells according to several aging markers whilst enabling them to return to their original identity.

Replication stress induces phosphorylation events within RIF1 intrinsically disordered region that are essential for RIF1's role in DNA replication fork protection.

An improved conditional gene-based association analysis framework guided by multiple variant-gene mapping strategies was built and evaluated based on its performance in predicting the potential susceptibility isoforms, genes, and tissues of schizophrenia.

The fate of duplicated transcription factors within budding yeast is described, providing insights into the mechanisms that shape transcriptional networks during evolution.

New open-source method contains all the tools for extracting open chromatin or RNA from thousands of single cells in parallel for <5% of the cost of state-of-the-art commercial alternatives, paving the way for whole-tissue atlasing and new protocol development.

A bulk barcoded quantitative trait locus approach increases the power and resolution of genotype-phenotype mapping in yeast, revealing that the genetic architecture of 18 complex traits is highly polygenic, and is characterized by widespread epistatic interactions and pleiotropic effects.

Bidirectional causal relationship between higher sedentary time and higher adiposity suggests that decreasing sedentary time is beneficial for weight management, but also that weight loss may help reduce sedentary time.

Development of a new tool to control the activity of the GAL4 in Drosophila allows researchers to switch transgene expression on in specific cell types by feeding them the plant hormone auxin.

Transcription factor proteins play an important role in modulating base damage formation and excision repair at the binding sites in the genome.