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    1. Medicine
    2. Neuroscience

    Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

    Jianxi Zhu, Gehua Zhen ... Xu Cao
    Osteoblastic PGE2 induces pain and OA progression by NaV1.8 modification and serves as a potential target multiple skeletal pain and degenerations.
    1. Medicine

    Meta-Research: COVID-19 medical papers have fewer women first authors than expected

    Jens Peter Andersen, Mathias Wullum Nielsen ... Reshma Jagsi
    Lockdowns in the United States caused by the COVID-19 pandemic appear related to a decrease in the number of women publishing research papers, especially as first authors.
    1. Epidemiology and Global Health
    2. Medicine

    Estimates of the global burden of Japanese encephalitis and the impact of vaccination from 2000-2015

    Tran Minh Quan, Tran Thi Nhu Thao ... Hannah Clapham
    Modelling analysis reveals the burden of Japanese Encephalitis is greater than previously thought, and although vaccination has reduced burden, there are remaining places with a great need for vaccination.
    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

    COVID-19: A Collection of Articles

    Edited by Diane M Harper et al.
    eLife has published the following articles on SARS-CoV-2 and COVID-19.
    1. Medicine
    2. Immunology and Inflammation

    Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

    Sara E Vazquez, Elise MN Ferré ... Mark S Anderson
    Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
    1. Medicine
    2. Immunology and Inflammation

    Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

    Frank L van de Veerdonk, Mihai G Netea ... Hans van der Hoeven
    The kinin-kallikrein system is a crucial target for the treatment of COVID-19.
    1. Medicine

    Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

    Jonathan R Volpatti, Yukari Endo ... James J Dowling
    A multi-species chemical screening platform reveals a conserved role for p38 inhibition in modulating ryanodine receptor-related phenotypes and is adaptable to a range of neuromuscular disorders.
    1. Medicine

    Drug Discovery: From worms to fish to mice

    Guy M Benian, Hyojung J Choo
    An multi-species approach can be used to identify small molecules with properties that might prove useful for the treatment of some neuromuscular diseases.
    Version of Record
    Insight
    1. Medicine

    Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

    Gian Paolo Rossi, Viola Sanga, Matthias Barton
    Current evidence does not suggest adverse effects of ACE inhibitors or ARBs in COVID-19 patients and, to the contrary, discontinuing these drugs in these patients may potentially be harmful.
    1. Medicine

    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

    Naga Suresh Adapala, Gaurav Swarnkar ... Yousef Abu-Amer
    Site-specific modification of NEMO facilitates RANKL signal specificity in myeloid progenitors and serves as a potential target to modulate inflammatory osteolysis through ISG15-dependent autophagy.