Browse our latest Medicine articles

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    1. Medicine
    2. Neuroscience

    Neurovascular sequestration in paediatric P. falciparum malaria is visible clinically in the retina

    Valentina Barrera, Ian James Callum MacCormick ... Simon Peter Harding
    Clinical, clinicopathological and image data from Malawian children shows that sequestration in P. falciparum cerebral malaria is visible clinically in the eye as orange retinal vessels and is strongly associated with death.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay, Emre Kiciman ... Andrey Rzhetsky
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Microbiology and Infectious Disease
    2. Medicine

    A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

    Isaie J Reuling, Lisanne A van de Schans ... Teun Bousema
    Controlled human malaria infection model allows the study of gametocyte biology and dynamics providing novel insights and tools in malaria transmission and elimination efforts.
    1. Medicine
    2. Neuroscience

    Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

    Roxanne Lofredi, Wolf-Julian Neumann ... Andrea A Kühn
    Bradykinesia in Parkinson's disease may be associated to a dopamine-dependent recruitment failure of subthalamic activity in short bursts of gamma synchrony.
    1. Cancer Biology
    2. Medicine

    Science Forum: Challenges in validating candidate therapeutic targets in cancer

    Jeffrey Settleman, Charles L Sawyers, Tony Hunter
    More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not.
    1. Medicine

    A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency

    Baptiste Fouquet, Patrycja Pawlikowska ... Micheline Misrahi
    Bilallelic mutations of FANCM, a DNA-damage response gene whose heterozygous mutations predispose to breast cancer, are involved in a familial case of Primary Ovarian Insufficiency establishing a link between infertility and cancer.
    1. Medicine

    Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

    Paul J Brighton, Yojiro Maruyama ... Jan Joris Brosens
    While acute senescence of decidualizing cells drives the inflammatory response underpinning uterine receptivity, subsequent clearance by activated natural killer cells transiently rejuvenates the cycling endometrium, enabling transition into a gestational tissue upon embryo implantation.
    1. Developmental Biology
    2. Medicine

    CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

    Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
    Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
    1. Epidemiology and Global Health
    2. Medicine

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin, Benjamin F Arnold ... Stephen P Luby
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Medicine

    Cardiovascular adaptation to hypoxia and the role of peripheral resistance

    Andrew S Cowburn, David Macias ... Randall S Johnson
    Radiotelemetric and genetic studies of peripheral tissue response show that a peripheral tissue can dynamically alter cardiovascular adaptation to changes in environmental oxygen.