Cell culture adaptation of SARS-CoV-2 is prevented on human airway cells with an active serine protease-mediated entry pathway, allowing the production of genetically stable virus stocks for laboratory experiments.
John A Buglino, Gaurav D Sankhe ... Michael S Glickman
M. tuberculosis, the bacterium that causes the disease tuberculosis, uses a signaling system that senses multiple products of the host's immune system to modify gene expression to colonize the lung.
When culturing SARS-CoV-2 in the laboratory it is vital to avoid deletions in the gene for the spike protein that could affect the interpretation of experiments.
ATG9-dependent autophagy is an essential pathway for long-term survival within the cyst in the parasite Toxoplasma gondii and could be exploited in future studies seeking interventions against persistent Toxoplasma infection.
Joseph T Clark, David A Christian ... Christopher A Hunter
Upon Toxoplasma gondii infection, IL-33 plays a critical role in driving early anti-parasite responses by innate lymphoid cells rendered responsive to its effects by infection.
Rita de Cassia Pessotti, Bridget L Hansen ... Matthew F Traxler
The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
