Poor intracellular availability and diffusion of weakly basic, small molecule drugs can be greatly enhanced by preventing ion trapping in crowded cellular environments.
Divyoj Singh, Sriram Ramaswamy ... Mohd Suhail Rizvi
A minimal mathematical model can explain the emergence of planar cell polarity in epithelial tissues using only three free parameters, namely the rate of protein binding to cell membrane, the intracellular protein concentration, and the steepness of tissue-level gradients.
Tommaso Amico, Samuel Toluwanimi Dada ... Amos Maritan
The scaling invariance of the droplet size distribution as a universal aspect of protein phase separation is reported, providing a quantitative approach to determinate the critical concentration for this process.
Intraspecific predator interference enables a wide range of consumer species to coexist with a limited variety of resources, explaining the paradox of the plankton and species diversity patterns across ecosystems.
Maria Cristina Cannarsa, Filippo Liguori ... Roberto Di Leonardo
Introducing the optorepressilator, a synthetic genetic oscillator that can be synchronized, entrained, and detuned by green light to precisely control periodic gene expression in single cells or entire bacterial populations.
Natanael Spisak, Gabriel Athènes ... Aleksandra M Walczak
HILARy is a new algorithm for grouping B-cell receptor sequences into distinct lineages, a crucial task to analyze immune response and memory through repertoire sequencing.
Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
