Browse our latest Structural Biology and Molecular Biophysics articles

Page 11 of 186
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

    Jianing Liu, Anokhi Shah ... Keni Vidilaseris
    Distinct asymmetric states in membrane-bound pyrophosphatases reveal how inhibitors block their activity and inform drug development.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Roles of the membrane-binding motif and the C-terminal domain of RNase E in localization and diffusion in E. coli

    Laura Troyer, Yu-Huan Wang ... Sangjin Kim
    Single-molecule imaging uncovers how distinct membrane-binding motifs and the intrinsically disordered C-terminal domain control RNase E’s membrane association and diffusion, linking structural divergence to RNA-processing dynamics in bacteria.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

    Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
    Full-length, autoinhibited LRRK2 assembles into distinct, shorter microtubule-bound filaments via a previously unobserved N-terminal repeat interface, revealing new structural states with potential therapeutic implications.
    Version of Record
    Short Report
    • Important
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Cryo-EM Reveals Regulatory Mechanisms Governing Substrate Selection and Activation of Human LONP1

    Jeffrey T Mindrebo, Lauren Alexandrescu ... Gabriel C Lander
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.
    1. Structural Biology and Molecular Biophysics

    Molecular Architecture and Function Mechanism of Tri-heteromeric GluN1-N2-N3A NMDA Receptors

    Zengwei Kou, Fenyong Yao ... Yidi Sun
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Decoding molecular mechanisms for loss-of-function variants in the human proteome

    Matteo Cagiada, Nicolas Jonsson, Kresten Lindorff-Larsen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
    1. Structural Biology and Molecular Biophysics

    Protein language model identifies disordered, conserved motifs implicated in phase separation

    Yumeng Zhang, Jared Zheng, Bin Zhang
    Conserved sequence motifs within intrinsically disordered protein regions act as evolutionary units that support phase separation and membraneless organelle formation.
Newer articles Older articles