Beyond genotype × environment interactions, which can be shared and identical across individuals, learning from uniquely individual experiences further defines and diversifies individual behaviour.
Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
Phospholipase Cβ3 is translocated and activated by the heterotrimeric G protein subunit Gαq at the plasma membrane, but the Gβγ heterodimer is required for maximum activation.
Intracellular zinc dynamically changes during sperm capacitation and regulates Slo3-mediated hyperpolarization, while directly inhibiting Slo3 currents through residues contributing to its slow dissociation.
Giovanni Rabuffo, Abhirup Bandyopadhyay ... Viktor Jirsa
Bridging biophysical neuron models with tractable population dynamics opens a route to whole-brain investigation of ion-driven pathological states such as epilepsy and their potential therapeutic targets.
A generalizable computational approach automatically identifies individual common marmosets to serve as support for presenting and analyzing behavioral tasks without relying on extensive manual work.
Depression-specific symptoms blunt mood responses to unexpected outcomes, whereas anxiety-specific symptoms amplify them in non-clinical participants, with depression-related blunting also replicated in patients with affective disorders.
Daniel Beaudet, Christopher L Berger, Adam G Hendricks
Single-molecule motility assays and live-cell imaging in neurons reveal that tau hyperphosphorylation disrupts the formation of cooperative tau envelopes along microtubules and lysosomal transport.
Utilizing the olfactory system of Drosophila, a critical period paradigm has provided new insight into the selectivity and longevity of the impact of early life experiences on sensory system circuitry.
Modularized spike sorting pipelines can identify performance bottlenecks, lower contribution barriers, and enable the development of highly accurate algorithms to turn extracellular recordings into spikes.
The rotational retinal flow generated by natural gaze stabilization is not merely visual noise to be subtracted but actively shapes human heading perception.
The open-source closed-loop system enables mice to learn modulation of cortical activity or movement by providing a platform for testing brain-behavior relationships in motor learning and neurorehabilitation research.
Michael A Savage, Cori Bertram ... Evelyne Sernagor
An interdisciplinary approach uncovers a never-before-seen multifaceted synchrony of developmental processes in the rodent retina which are driven by purinergic signalling from apoptotic retinal ganglion cells.
Tooth plucking triggers a rapid, coordinated regeneration program in cichlids, accelerating replacement more than threefold through temporally organized epithelial, mesenchymal, immune, vascular, and neural signaling.
Joel Kowalewski, Barbara F Baer-Imhoof ... Anandasankar Ray
Honey bee olfactory aversion can be modeled using machine learning to iteratively discover bee-selective repellents, validated in free-flying assays, that can potentially reduce contact with pesticides.
William Roseby, Jonathan AC Menzies ... Claudio R Alonso
Behavioural, optogenetic, and gene expression analyses demonstrate that regional mechanosensory processes instructed by Hox gene inputs are essential for postural control in Drosophila larvae linking local body features to behaviour.
A well-orchestrated machinery for L-leucine uptake is functional in Mycobacterium tuberculosis, which is important for the intracellular survival of the tuberculosis (TB) pathogen.
In vivo live imaging, quantitative analysis, and computational modeling reveal that wound-induced epithelial cell fusion accelerates epithelial repair through several likely mechanisms.
A mouse model of O-GlcNAc transferase associated intellectual disability reveals brain structural and cognitive deficits providing an important platform for mechanistic and therapeutic discovery.
Climate warming can silently replace cold-adapted native lineages with warm-adapted ones through asymmetric introgression and physiological advantages, a process overlooked by species-level forecasts.
In an auditory statistical learning experiment, infants at high likelihood for autism showed reduced neural entrainment to syllables, atypical developmental trajectories for word segmentation, and diminished novelty orientation to words.
Temporary darkness enhances the neural separability of tactile textures in the rat somatosensory cortex, revealing how sensory coding rapidly adapts to the absence of vision.
An optimized rabies virus-based methodology enables efficient monosynaptic input mapping and circuit reconstruction from genetically defined neurons in larval zebrafish.
Juan Bosco Gracia Alvira, Stefanie Migotti ... Christian Schlötterer
Changes in abiotic factors, such as temperature, can affect the host fitness indirectly by modulating subspecies dynamics of key taxa, which are usually overlooked in microbiome research.
OCRL deficiency is associated with mitochondrial dysfunction, altered ciliary signaling, and disrupted neural cell-state regulation across multiple experimental models of Lowe syndrome.
Inhibiting the mitochondrial bc1-complex disrupts energy production in mature Toxoplasma gondii bradyzoites, suggesting a metabolic vulnerability in the parasite's chronic, drug-resistant stage.
A comprehensive two-hybrid map of the Set1C interactome broadens understanding of Set1C subunit functions and identifies a novel link between Set1C and arginine methylation.
The perceived value of task outcomes, rather than task aversiveness, predicts reduced everyday procrastination following transcranial direct current stimulation, and offers a potential target for behavioral intervention.
Social context modulates innate defensive behaviors in a rank- and threat-dependent manner, while threat experience reinforces social roles, revealing a bidirectional interplay between defensive and social behavior.
Daniel Haertter, Lara Hauke ... Christoph F Schmidt
A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.
Malaria parasites have evolved a noncanonical function for the apicoplast acyl carrier protein in stabilizing pyruvate kinase II, a metabolic hub essential for isoprenoid synthesis and parasite survival.
Michele Marconcini, Steeve Cruchet ... Richard Benton
Selection of animal populations and of cultured cells provides complementary datasets to identify candidate genes involved in conferring resistance to a natural insecticide.
Revealing a role for NINJ2 in maintaining lysosomal homeostasis and preventing ferroptosis, laying the foundation for the development of cancer therapeutics targeting NINJ2.
Rémi Pichon, Magda E Lotkowska ... Gabriel Rinaldi
Establishment of sexually dimorphic schistosomes entirely in vitro from mechanically transformed cercariae paves the way for uncovering the cellular and molecular cues underlying development, providing potential targets for novel control strategies.
Repeat variation in wild Arabidopsis thaliana arises from centromere-proximal sequence changes and rare variants in DNA replication, repair, and methylation genes, consistent with purifying selection constraining genome expansion.
Septin-associated kinases functions in an adaptable regulatory network with overlapping functions to coordinate septin organization with actomyosin ring machinery to ensure robust cytokinesis in Saccharomyces cerevisiae.
Anne R Van Arsdale, Olga Meshcheryakova ... Jack Lenz
HPV-human DNA junction detection in serum cell-free DNA unambiguously identifies tumor genetic-signatures of integrated viral DNA from HPV-induced cancers and could be useful for recurrence prediction and monitoring residual disease.
A streamlined seven-component cell-free expression platform simplifies reaction design while maintaining high productivity and enabling robust synthesis of challenging proteins for diverse applications.
At moderate densities, small mammalian herbivores can enhance livestock weight gains by suppressing toxic plants and improving both the abundance and nutritional quality of palatable forage in rangelands.
Primordial cardiomyocytes play an essential role in myocardial morphogenesis and coronary vascularization, but not in adult zebrafish heart regeneration.
A genome-wide RNA interference screen identified cellular processes that modulate the phase separation of a TDP-43 mutant, providing a framework for dissecting the link between its phase behavior and disease-associated aggregation.
Nahir Guadalupe Gazal, Maria Jose Castellanos-Montiel ... Nicolás Unsain
An actin-nucleation-dependent assembly of the axonal membrane skeleton reveals that βII-spectrin gap-and-patch patterns in human motor neurons represent an intermediate stage of cytoskeletal maturation.
Layer 6b neurons shape state-dependent brain rhythms and responses to orexin, revealing an underappreciated cortical mechanism that may help explain disrupted sleep-wake regulation in neurodevelopmental and psychiatric disorders more broadly.
Single-cell observations refute the expectation that centrosome positioning is critical for epithelial cell polarization while showing that proper positioning enhances polarization efficiency.
In complex life cycle taxa, the relationship between functional traits and threat status varies across developmental stages, making adult‑based threat predictions insufficient to reflect risks faced during other life stages.
Justin D Shin, Michael Satchell ... Shantanu P Jadhav
Rapid eye movement (REM) sleep organizes sparse, sequential cortical reactivation through chains of prefrontal high-frequency oscillations coupled to hippocampal theta, an inter-regional dialogue distinct from that of non-REM ripples.
Anda de Witte, Anouck Matthijs ... Jean-Jacques Orban de Xivry
Cerebellar-dependent functions are mostly maintained or even enhanced across the lifespan, with cerebellar-mediated motor abilities remaining intact despite degeneration, in contrast to non-cerebellar measures.
Warm temperature promotes gonadal transformation of ricefield eel by inducing the expression of male pathway genes in ovaries via the Trpv4-pStat3-Kdm6b-Dmrt1 axis.
Polo-like kinase phosphorylation of the centrin arm-localized orphan kinesin KIN-G disrupts its microtubule-binding activity and inhibits centrin arm biogenesis in trypanosomes.
Extracellular DNA degrades at markedly different rates across soils and sequences, substantially biasing estimates of prokaryotic abundance, diversity, and community composition.
Noradrenergic tone varies with arousal state, is inversely correlated with hippocampal ripple and sleep spindle oscillations, and differs according to ripple–spindle coupling, with potential implications for synaptic and systems consolidation.
Multimodal data-driven computational modeling reveals that realistic cortical connectivity can generate more macroscopic traveling waves than local or uniform connectivity in the mouse cortex.
Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
Jenny A Hurcombe, Lusyan Dayalan ... Richard JM Coward
Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.
Computational modeling and human pilot study present a mechanistic framework explaining the capacity for transcutaneous tibial nerve stimulation to induce excitatory or inhibitory effects based on electrical stimulation frequency alone.
Zahra Seraj, Ximena Zottig ... Andrei A Korostelev
Cryogenic electron microscopy of cellular extracts can visualize atomic details and discover new interactions between biological molecules, such as the interactions of the ribosome, the protein-making machinery, with essential proteins to regulate cellular functions.
Vocalizations of nonhuman primates, especially when acoustic and phylogenetic proximity is the highest, enhance human brain activity in the anterior temporal lobe.
Tommy Clausner, José P Marques ... Mathilde Bonnefond
Combined human laminar EEG–fMRI reveals feature-specific gamma band activity, and dissociates general (lower frequency) from feature-specific (higher frequency) alpha band activity related to superficial and deep cortical layers.
The tuft dendrites of neurons in the premotor cortex are uniquely selective for corrective actions, suggesting a specialized role in motor control and motor learning.
Marisa J Brothwell, Guoshen Cao ... Katsuhiko Funai
Metabolic dysfunction-associated steatotic liver disease is associated with reduced mitochondrial cardiolipin concentration in mice and humans, and cardiolipin deficiency was sufficient to drive steatosis and fibrosis in the liver.
Artificial intelligence and multimodal neuroimaging revealed brain state-dependent differences in the functional connectivity prediction of memory and identified the dopamine-modulated brain cognition gap as a marker of vulnerability to compromised brain function.
Laura C Bohorquez, Henrik Strahl ... Leendert Hamoen
Diffusion rate difference between MinD monomer and dimer is important for MinD protein gradient formation in B. subtilis, and not membrane affinity difference.
Hengqi Betty Zheng, Benjamin A Doran ... Leslie S Kean
Single-cell profiling of untreated pediatric Crohn’s disease identifies coordinated immune and epithelial cell states that stratify patients by disease severity and future anti-TNF response.
Jonathan Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
Automated, long-term tracking reveals that social rank in male mice is a stable individual trait that persists across group changes, with chasing serving to negotiate rank among dominant individuals.
