Diverse insect movement behaviours, from scans, pirouettes, and loops to sweeping oscillations, can emerge from conserved neural circuits, with forward speed balancing goal-directed travel against exploratory sampling.
Nuclear A/B compartments are dramatically remodeled by S‑phase entry and weaken in G2, revising the model of cell‑cycle chromatin dynamics and placing G1/S as a key transition.
High-throughput monitoring of glucose-evoked calcium oscillations in uniform 3D β-cell spheroids enables efficient discovery of compounds that enhance insulin secretion.
CD1c-autoreactive T-cells couple infection-associated lipid recognition with cytotoxic and antimicrobial activity, revealing a previously underappreciated arm of human immunity to tuberculosis.
Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
NK2R is a molecular switch linking tachykinin signaling to intestinal lipid handling, mucosal inflammation and gut microbiota, positioning NK2R-targeted peptide therapeutics for cardiometabolic and inflammatory bowel diseases.
A type VI secretion system transferred between gut bacteria via a mobile genetic element stabilizes its native host strain, but yields only transient benefits in a new species.
Hugo T Chow-Wing-Bom, Matteo Lisi ... Tessa M Dekker
Model‑based fMRI contrast‑sensitivity mapping provides a fixation‑tolerant, large‑field measure of cortical visual function that sensitively detects, localizes, and tracks visual field loss and recovery.
Integrating genome-wide maps of chromatin accessibility and sequence conservation provides an accessible low-cost approach for identifying cis-regulatory elements in large genomes, validated in the emerging model Parhyale.
