Browse our Research Articles

Page 3 of 1,518
    1. Developmental Biology

    Bidirectional redistribution of actomyosin drives epithelial invagination in ascidian siphon tube morphogenesis

    Jinghan Qiao, Pengyu Yu ... Bo Dong
    Bidirectional relocation of actomyosin as a novel mechanism drives invagination in developing organs.
    1. Neuroscience

    A cortical–hippocampal communication undergoes rebalancing after new learning

    Arron F Hall, Dong V Wang
    The anterior cingulate cortex selectively reorganizes communication with superficial CA1 neurons during sharp-wave ripples to balance memory consolidation following new learning.
    1. Neuroscience

    Negative affect influences the computations underlying food choice in bulimia nervosa

    Blair RK Shevlin, Loren Gianini ... Laura A Berner
    In bulimia nervosa, negative affect exaggerates a taste-before-health bias in food decision-making, and this bias is associated with more frequent out-of-control eating.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Beyond genotype × environment interactions, which can be shared and identical across individuals, learning from uniquely individual experiences further defines and diversifies individual behaviour.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Phospholipase Cβ3 is translocated and activated by the heterotrimeric G protein subunit Gαq at the plasma membrane, but the Gβγ heterodimer is required for maximum activation.
    1. Cell Biology
    2. Developmental Biology

    Zinc is a key regulator of the sperm-specific K+ channel (Slo3) function

    Rizki Tsari Andriani, Tanadet Pipatpolkai ... Takafumi Kawai
    Intracellular zinc dynamically changes during sperm capacitation and regulates Slo3-mediated hyperpolarization, while directly inhibiting Slo3 currents through residues contributing to its slow dissociation.
    1. Neuroscience

    Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms

    Giovanni Rabuffo, Abhirup Bandyopadhyay ... Viktor Jirsa
    Bridging biophysical neuron models with tractable population dynamics opens a route to whole-brain investigation of ion-driven pathological states such as epilepsy and their potential therapeutic targets.
    1. Neuroscience

    Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and anxiety

    Zhihao Wang, Ting Wang ... Pengfei Xu
    Depression-specific symptoms blunt mood responses to unexpected outcomes, whereas anxiety-specific symptoms amplify them in non-clinical participants, with depression-related blunting also replicated in patients with affective disorders.
    1. Neuroscience

    PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons

    Magdalena Vitar, Daniel Prieto ... Federico F Trigo
    Apical PKD2L1 channels generate phasic and sustained currents that together make spinal cerebrospinal fluid-contacting neurons exquisite pH sensors.
    1. Computational and Systems Biology
    2. Developmental Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids

    Catherine Triandafillou, Pranav Sompalle ... Arjun Raj
    Detailed, single-cell spatial gene expression across multiple gastruloids highlights macro-scale organizational consistency, simultaneous with variance in meso-scale patterning.