Browse our latest Genetics and Genomics articles

Pulsatile chromatin opening stimulated by naturally-occurring plasma growth hormone pulses is one of two GH-determined mechanisms that establish widespread sex differences in hepatic chromatin accessibility and epigenetic regulation, both closely linked to sex differences in liver gene transcription and function.

LRRC23 is a radial spoke 3 head component essential for normal sperm motility and fertility in mammals.

In this Special Issue we present a range of studies that showcase novel approaches that researchers are exploring to better decipher the link between genotype and phenotype.

A comprehensive platform is established for the evaluation of both current and future individuals afflicted with the UBA5-associated developmental and epileptic encephalopathy.

A geographically and temporally restricted genomic surveillance study concludes that Enterobacterales plasmid dissemination between human and non-human niches might be occurring at greater rates than previously estimated.

Live imaging and taste behavior analyses show that related members of the Gr28 gene subfamily are expressed in largely non-overlapping sets of neurons and mediate opposing taste behaviors.

Phylogenomics reveals the timeline over which marine bacteria and archaea colonized the oceans and shows the geological context of their diversification.

Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.

Multidimensional study of signaling pathways and epigenomics investigates how TCR (T cell receptor) signaling and chromatin landscape interpaly and impact on Treg stability.

Chromatin profiling of Drosophila testes reveals activation of the transcriptional program of the germline, widespread changes in RNA polymerase progression, and the absence of chromosomal regulation across the X chromosome.