Browse our latest Genetics and Genomics articles

Enhanced proteasomal degradation of TNFAIP3 proteins carrying missense variations is one of the pathophysiological mechanisms underlying HA20.

Stdpopsim, a framework for generating realistic chromosome-scale simulations, is expanded to facilitate simulations for non-model species, resulting in insights into how such simulations should be designed.

The allele-specific gene-editing drug is expected to make RHO-T17M-associated retinitis pigmentosa therapy a reality.

Drosophila experience two hunger states, one driven by need and the other by pleasure, which arise from unique neural substrates.

Gene-editing to repair non-functional transcriptional elements in the endogenous promoter of δ-globin increases overall expression of adult hemoglobin 2 (HbA2), providing proof-of-concept for a therapeutic avenue to treat β-hemoglobinopathies.

Strongly protective effect conferred by the Dantu blood group variant against early, non-clinical, Plasmodium falciparum malaria infections in vivo.

Belly roll, Bero, an Ly6/α-neurotoxin family protein, is identified as a critical modulator of peptidergic interneurons in Drosophila melanogaster, shedding light on genetic regulations of nociceptive escape behaviors and providing a potential target for future studies on pain perception.

While tau and aging have highly overlapping differential gene expression signatures, they diverge in the affected cell types, with aging having a wide-ranging impact and tau-triggered changes instead polarized to excitatory neurons and glia.

The regulatory role of thousands of upstream open-reading frames were measured and used to determine the relative influences of sequence, structural, and positional features on translation regulation and nonsense-mediated decay.