Hengqi Betty Zheng, Benjamin A Doran ... Leslie S Kean
Single-cell profiling of untreated pediatric Crohn’s disease identifies coordinated immune and epithelial cell states that stratify patients by disease severity and future anti-TNF response.
MOTS-c, a mitochondrial-encoded microprotein, has immunological origins and functions, revealing for the first time that our immune system is encoded by both co-evolved nuclear and mitochondrial genomes.
In a mouse model of E. coli meningitis, non-myeloid TLR4 signaling is a key determinant of the inflammatory response in all leptomeningeal cells and of the increase in vascular permeability.
