Browse our latest Computational and Systems Biology articles

Inhibition of activity in the right frontal eye fields reduces the amplifying effect of gaze in value-based choice.

Proteomics and metabolic modeling revealed that the 'knallgas' bacterium Cupriavidus necator utilizes only a fraction of its proteome and keeps large enzyme reserves as an adaption to variable environments.

Molecular, cellular, and computational analyses reveal key insights into PP2A/B55α's mechanisms of substrate recruitment and active site engagement, and facilitate identification/validation of new substrates, a step towards understanding PP2A/B55α's role in multiple cellular processes.

Countrywide agent-based simulations with building-level resolution reveal the importance of demographic repartition and population density on epidemic dynamics of respiratory infections.

Comprehensive analysis of alternative splicing from human droplet-based scRNA-seq data identifies genes with regulated splicing conserved in mouse and mouse lemur.

Behavioral, optogenetic, and computational modeling analyses show that the roundworm Caenorhabditis elegans uses a relaxation oscillation mechanism to generate rhythmic locomotor patterns.

Chromosome replication and a different inter-division process both contribute to division control during unperturbed growth, but if division is delayed by increasing cell width the inter-division process becomes solely rate-limiting.

Artificial evolution discovers biophysically plausible plasticity rules for spiking networks that perform competitively with and even outperform labor-intensive human-designed models in various learning scenarios, while providing new views on experimental data.

Accurate identification and quantification of various circRNA isoforms.

A parsimonious biophysical model correctly predicts the conserved expression stoichiometry of core bacterial mRNA translation factors, providing intuitive and quantitative design principles for in vivo pathway construction.