Browse our latest Genetics and Genomics articles

HIV transmissions into intervention communities from control communities in the Botswana/Ya Tsie trial were similar to the reverse at baseline, and 10 times more common post-baseline, concordant with a predicted benefit of a universal test-and-treat HIV prevention intervention.

Horizontal gene transfer can potentially merge genomes from distinct bacterial species, but isolation in different hosts creates a physical barrier to gene flow.

Augmentation of progestin signaling promotes testis development and spermatogenesis independent from andorgen signaling in zebrafish.

259 CpGs associated with season of conception in rural Gambians constitute a valuable resource for investigating epigenetic mechanisms linking early exposures to lifelong health and disease.

Single myofiber ATAC-Seq provides assessment of chromatin accessibility of a single myofiber without the confounding effects of other cell types present in skeletal muscle.

Genetic analyses reveal biological insight of a novel risk locus into systemic lupus erythematosus susceptibility.

Body mass index and adipose distribution have opposing and broad effects on human blood trait variation by Mendelian randomization analysis, helping to clarify the complex interplay between cardiometabolic traits and hematopoiesis at the genetic level.

Cross-sectional transcriptome analysis of mice, covering the whole lifespan, reveals that inter-tissue divergence during development is accompanied by a weaker but widespread convergence during ageing.

Naturally short-lived turquoise killifish undergo systemic and mucosal spontaneous decline in antibody-repertoire diversity during aging, recapitulating in a few months the aging-dependent decline of adaptive immunity.

Epigenetic scores for blood protein levels identify those at risk of multiple age-related morbidities, up to 14 years prior to onset.