Browse our latest Genetics and Genomics articles

Double-stranded precursors of siRNAs involved in RNA-directed DNA methylation have initiating sequences and overhangs imparted by the RNA polymerases that synthesize them, programming alternative dicing reactions that diversify the siRNA pool.

A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.

Behavioural and physiological stress response components are integrated on the major axis of genetic covariation, with implications for health and the understanding of the evolutionary response to stressors.

Heterochromatin proteins like the SIR complex in budding yeast use different mechanisms for recruitment to nucleation sites and long-range spread to create a domain of transcriptional silencing.

Mouse molecular genetics and in vivo functional studies reveal that thyroid hormone is necessary for punctual proximal femur head development by a mechanism that differs temporally and molecularly from the secondary ossification center at the distal femur.

This first comparison of different methodologies to estimate germline mutation rate from pedigrees resulted in almost a 2-fold variation in the estimated rates, discrepancies mainly caused by different filtering methods.

Embryoid bodies produce diverse cell types and can enable the study of gene regulatory dynamics at unprecedented spatial and temporal resolution.

Over 40% of CDKN2A variants of uncertain significance identified in patients with pancreatic cancer are functionally deleterious and can be reclassified as likely pathogenic with implications for care of patients and their relatives.

Alternative 9-1-1 complexes have evolved to play essential roles in mammalian meiosis and function to activate the protein kinase ATR and promote key meiotic events necessary for fertility.

Combining compartment- and cell-type specific transcriptomic approaches reveals FMRP regulation of synaptic regulators in the dendrites and chromatin regulators in the cell bodies of CA1 neurons.